Detailed information of TA system TA148219

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2643509..2643771
• Replicon: chromosome
• Accession: NZ_CP047839
• Organism: Staphylococcus aureus strain UP_678

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: -
• Locus tag: E3S85_RS12940
• Protein ID: WP_073392962.1
• Coordinates: 2643509..2643613 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2643608..2643771 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S85_RS12925	2640305..2641087	+	783	WP_000908186.1	ABC transporter ATP-binding protein	-
E3S85_RS12930	2641155..2642012	+	858	WP_000370937.1	Cof-type HAD-IIB family hydrolase	-
E3S85_RS12935	2642671..2642829	-	159	WP_001792784.1	hypothetical protein	-
E3S85_RS12940	2643509..2643613	+	105	WP_073392962.1	hypothetical protein	Toxin
-	2643608..2643771	-	164	-	-	Antitoxin
E3S85_RS12945	2644055..2645146	-	1092	WP_000495684.1	hypothetical protein	-
E3S85_RS12950	2645412..2646392	-	981	WP_000019741.1	CDF family zinc efflux transporter CzrB	-
E3S85_RS12955	2646394..2646714	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S85_RS12960	2646866..2647531	+	666	WP_001024099.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3920.80 Da
• Isoelectric Point: 5.5724

>T148219 WP_073392962.1 NZ_CP047839:2643509-2643613 [Staphylococcus aureus]
MLLLERTSMSDFEMLMIVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148219 NZ_CP063476:c3061081-3060731 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCTCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT148219 NZ_CP047839:c2643771-2643608 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Antitoxin