Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2383469..2383986 Replicon chromosome
Accession NZ_CP047839
Organism Staphylococcus aureus strain UP_678

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag E3S85_RS11590 Protein ID WP_000251928.1
Coordinates 2383720..2383986 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag E3S85_RS11585 Protein ID WP_000584497.1
Coordinates 2383469..2383720 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S85_RS11555 2379169..2379888 + 720 WP_000479573.1 amino acid ABC transporter permease -
E3S85_RS11560 2379885..2380616 + 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
E3S85_RS11565 2380713..2381963 - 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
E3S85_RS11570 2382218..2382580 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S85_RS11575 2382599..2383198 + 600 WP_000162804.1 DsbA family protein -
E3S85_RS11580 2383205..2383305 + 101 Protein_2246 hypothetical protein -
E3S85_RS11585 2383469..2383720 + 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S85_RS11590 2383720..2383986 + 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
E3S85_RS11595 2384279..2385826 + 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S85_RS11600 2386012..2386479 + 468 WP_000153340.1 SRPBCC domain-containing protein -
E3S85_RS11605 2386566..2386748 + 183 WP_000079140.1 hypothetical protein -
E3S85_RS11610 2386951..2387775 + 825 WP_000594640.1 formate/nitrite transporter family protein -
E3S85_RS11615 2388243..2388779 + 537 WP_000024292.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T148218 WP_000251928.1 NZ_CP047839:2383720-2383986 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148218 NZ_CP063476:c2802721-2802407 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT148218 WP_000584497.1 NZ_CP047839:2383469-2383720 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT148218 NZ_CP063476:c2802957-2802724 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References