Detailed information of TA system TA148216

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2358501..2358685
• Replicon: chromosome
• Accession: NZ_CP047839
• Organism: Staphylococcus aureus strain UP_678

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S85_RS11455
• Protein ID: WP_000482647.1
• Coordinates: 2358501..2358608 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2358625..2358685 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S85_RS11430	2353863..2354336	+	474	WP_000456496.1	GyrI-like domain-containing protein	-
E3S85_RS11435	2354459..2355670	-	1212	WP_001191919.1	multidrug effflux MFS transporter	-
E3S85_RS11440	2355852..2356511	-	660	WP_000831298.1	membrane protein	-
E3S85_RS11445	2356571..2357713	-	1143	WP_001176855.1	glycerate kinase	-
E3S85_RS11450	2357981..2358367	+	387	WP_000779351.1	flippase GtxA	-
E3S85_RS11455	2358501..2358608	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2358625..2358685	-	61	-	-	Antitoxin
E3S85_RS11460	2359256..2361019	+	1764	WP_001064829.1	ABC transporter ATP-binding protein/permease	-
E3S85_RS11465	2361044..2362777	+	1734	WP_000486505.1	ABC transporter ATP-binding protein/permease	-
E3S85_RS11470	2363008..2363175	+	168	Protein_2224	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T148216 WP_000482647.1 NZ_CP047839:2358501-2358608 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148216 NZ_CP063476:2387319-2387537 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148216 NZ_CP047839:c2358685-2358625 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin