Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2326847..2327370 Replicon chromosome
Accession NZ_CP047839
Organism Staphylococcus aureus strain UP_678

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag E3S85_RS11315 Protein ID WP_000074047.1
Coordinates 2327104..2327370 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag E3S85_RS11310 Protein ID WP_000587617.1
Coordinates 2326847..2327104 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S85_RS11290 2321925..2323118 + 1194 WP_160176091.1 MFS transporter -
E3S85_RS11295 2323342..2324091 - 750 WP_000072447.1 CPBP family intramembrane metalloprotease -
E3S85_RS11300 2324287..2325864 + 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
E3S85_RS11305 2326032..2326487 - 456 WP_000732090.1 YehR family lipoprotein -
E3S85_RS11310 2326847..2327104 + 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S85_RS11315 2327104..2327370 + 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
E3S85_RS11320 2327726..2328802 + 1077 WP_001076679.1 M42 family metallopeptidase -
E3S85_RS11325 2329148..2329810 + 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
E3S85_RS11330 2329803..2330579 + 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
E3S85_RS11335 2330973..2332160 + 1188 WP_000026190.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T148215 WP_000074047.1 NZ_CP047839:2327104-2327370 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T148215 NZ_CP063476:c2359737-2359435 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCTGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT148215 WP_000587617.1 NZ_CP047839:2326847-2327104 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT148215 NZ_CP063476:c2359399-2359058 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References