Detailed information of TA system TA148207

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 504679..505258
• Replicon: chromosome
• Accession: NZ_CP047839
• Organism: Staphylococcus aureus strain UP_678

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: E3S85_RS02695
• Protein ID: WP_001025401.1
• Coordinates: 504679..504924 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	504893..505258 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S85_RS02655	500935..501549	+	615	WP_000191457.1	hypothetical protein	-
E3S85_RS02660	501546..501692	-	147	WP_001013104.1	hypothetical protein	-
E3S85_RS02665	501782..502177	-	396	WP_000449655.1	hypothetical protein	-
E3S85_RS02670	502206..502640	-	435	WP_160175986.1	hypothetical protein	-
E3S85_RS02675	502657..503115	-	459	WP_054188988.1	toxin	-
E3S85_RS02680	503137..503463	-	327	WP_000455972.1	helix-turn-helix domain-containing protein	-
E3S85_RS02685	503626..503835	+	210	WP_001114715.1	helix-turn-helix transcriptional regulator	-
E3S85_RS02690	503874..504650	+	777	WP_160175987.1	Rha family transcriptional regulator	-
E3S85_RS02695	504679..504924	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
E3S85_RS02700	504893..505258	-	366	WP_160175988.1	hypothetical protein	Antitoxin
E3S85_RS02705	505313..505528	+	216	WP_001036302.1	hypothetical protein	-
E3S85_RS02710	505553..505816	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
E3S85_RS02715	505829..505990	+	162	WP_001285963.1	DUF1270 family protein	-
E3S85_RS02720	506069..506392	+	324	WP_000175000.1	hypothetical protein	-
E3S85_RS02725	506407..506769	+	363	WP_072426435.1	hypothetical protein	-
E3S85_RS02730	506766..507932	+	1167	WP_160175989.1	DUF2800 domain-containing protein	-
E3S85_RS02735	507958..508515	+	558	WP_072426433.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T148207 WP_001025401.1 NZ_CP047839:504679-504924 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T148207 NZ_CP063476:672765-673016 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT148207 NZ_CP047839:c505258-504893 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGGCAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin