Detailed information of TA system TA148205

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 176471..176651
• Replicon: chromosome
• Accession: NZ_CP047839
• Organism: Staphylococcus aureus strain UP_678

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3S85_RS01065
• Protein ID: WP_001801861.1
• Coordinates: 176556..176651 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	176471..176528 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S85_RS01040	171884..174304	-	2421	WP_033844720.1	polysaccharide lyase 8 family protein	-
E3S85_RS01045	174829..175271	+	443	Protein_171	DUF1433 domain-containing protein	-
E3S85_RS01050	175271..175714	+	444	WP_000731421.1	DUF1433 domain-containing protein	-
E3S85_RS01055	175714..176157	+	444	WP_001037039.1	DUF1433 domain-containing protein	-
E3S85_RS01060	176332..176433	-	102	WP_001791232.1	hypothetical protein	-
-	176471..176528	+	58	-	-	Antitoxin
E3S85_RS01065	176556..176651	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
E3S85_RS01070	177102..177548	+	447	WP_000747804.1	DUF1433 domain-containing protein	-
E3S85_RS01075	177741..178310	+	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
E3S85_RS01080	178310..179677	+	1368	WP_001093574.1	FRG domain-containing protein	-
E3S85_RS01085	179826..180398	-	573	WP_000414222.1	hypothetical protein	-
E3S85_RS01090	180496..180840	-	345	WP_000627550.1	DUF3969 family protein	-
E3S85_RS01095	180881..181507	-	627	WP_000669038.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	169949..171595	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T148205 WP_001801861.1 NZ_CP047839:c176651-176556 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T148205 NZ_CP063473:c4334876-4334769 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT148205 NZ_CP047839:176471-176528 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin