Detailed information of TA system TA148185

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2621925..2622203
• Replicon: chromosome
• Accession: NZ_CP047835
• Organism: Staphylococcus aureus strain UP_883

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3S91_RS12870
• Protein ID: WP_001802298.1
• Coordinates: 2621925..2622029 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2622025..2622203 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S91_RS12855	2618722..2619504	+	783	WP_000908175.1	ABC transporter ATP-binding protein	-
E3S91_RS12860	2619572..2620429	+	858	WP_000370926.1	Cof-type HAD-IIB family hydrolase	-
E3S91_RS12865	2621087..2621245	-	159	WP_001792784.1	hypothetical protein	-
E3S91_RS12870	2621925..2622029	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2622025..2622203	-	179	-	-	Antitoxin
E3S91_RS12875	2622471..2623562	-	1092	WP_000495671.1	lytic regulatory protein	-
E3S91_RS12880	2623828..2624808	-	981	WP_000019745.1	CDF family zinc efflux transporter CzrB	-
E3S91_RS12885	2624810..2625130	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3S91_RS12890	2625282..2625947	+	666	WP_001024093.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148185 WP_001802298.1 NZ_CP047835:2621925-2622029 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148185 NZ_CP063473:c880064-879786 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT148185 NZ_CP047835:c2622203-2622025 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin