148183

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2360436..2360953 Replicon chromosome
Accession NZ_CP047835
Organism Staphylococcus aureus strain UP_883

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E3S91_RS11530 Protein ID WP_000113262.1
Coordinates 2360687..2360953 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3S91_RS11525 Protein ID WP_000584499.1
Coordinates 2360436..2360687 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S91_RS11495 2356134..2356853 + 720 WP_000479576.1 amino acid ABC transporter permease -
E3S91_RS11500 2356850..2357581 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3S91_RS11505 2357678..2358928 - 1251 WP_001012227.1 FemA/FemB family glycyltransferase FmhA -
E3S91_RS11510 2359183..2359545 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S91_RS11515 2359564..2360163 + 600 WP_000162813.1 DsbA family protein -
E3S91_RS11520 2360170..2360271 + 102 WP_001791744.1 hypothetical protein -
E3S91_RS11525 2360436..2360687 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S91_RS11530 2360687..2360953 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E3S91_RS11535 2360988..2361059 + 72 Protein_2231 hypothetical protein -
E3S91_RS11540 2361248..2362798 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S91_RS11545 2362984..2363451 + 468 WP_000153344.1 SRPBCC domain-containing protein -
E3S91_RS11550 2363535..2363717 + 183 WP_000230294.1 hypothetical protein -
E3S91_RS11555 2363934..2364758 + 825 WP_000572040.1 formate/nitrite transporter family protein -
E3S91_RS11560 2364991..2365527 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T148183 WP_000113262.1 NZ_CP047835:2360687-2360953 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148183 NZ_CP063473:307013-307186 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGATCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT148183 WP_000584499.1 NZ_CP047835:2360436-2360687 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT148183 NZ_CP063473:306689-306985 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References