Detailed information of TA system TA148181

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2335394..2335578
• Replicon: chromosome
• Accession: NZ_CP047835
• Organism: Staphylococcus aureus strain UP_883

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: E3S91_RS11395
• Protein ID: WP_000482652.1
• Coordinates: 2335394..2335501 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2335518..2335578 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S91_RS11370	2330756..2331229	+	474	WP_000456484.1	GyrI-like domain-containing protein	-
E3S91_RS11375	2331352..2332563	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S91_RS11380	2332745..2333404	-	660	WP_000831298.1	membrane protein	-
E3S91_RS11385	2333464..2334606	-	1143	WP_111259058.1	glycerate kinase	-
E3S91_RS11390	2334874..2335260	+	387	WP_000779357.1	flippase GtxA	-
E3S91_RS11395	2335394..2335501	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2335518..2335578	-	61	-	-	Antitoxin
E3S91_RS11400	2336148..2337911	+	1764	WP_001064809.1	ABC transporter ATP-binding protein/permease	-
E3S91_RS11405	2337936..2339669	+	1734	WP_031918671.1	ABC transporter ATP-binding protein/permease	-
E3S91_RS11410	2339900..2340067	+	168	Protein_2206	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148181 WP_000482652.1 NZ_CP047835:2335394-2335501 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148181 NZ_CP063469:c71599-71312 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCAAAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGATTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGCAGCAACGTTTATCATCTCGCCAGTGAACGGATGAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148181 NZ_CP047835:c2335578-2335518 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin