Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2296954..2297477 Replicon chromosome
Accession NZ_CP047835
Organism Staphylococcus aureus strain UP_883

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag E3S91_RS11225 Protein ID WP_000074045.1
Coordinates 2297211..2297477 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag E3S91_RS11220 Protein ID WP_000587619.1
Coordinates 2296954..2297211 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S91_RS11200 2292019..2293212 + 1194 WP_000675402.1 MFS transporter -
E3S91_RS11205 2293450..2294199 - 750 WP_000072440.1 hypothetical protein -
E3S91_RS11210 2294394..2295971 + 1578 WP_000143502.1 FMN-binding glutamate synthase family protein -
E3S91_RS11215 2296139..2296594 - 456 WP_000732082.1 DUF1307 domain-containing protein -
E3S91_RS11220 2296954..2297211 + 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S91_RS11225 2297211..2297477 + 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
E3S91_RS11230 2297833..2298909 + 1077 WP_160193099.1 M42 family metallopeptidase -
E3S91_RS11235 2299157..2299819 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
E3S91_RS11240 2299812..2300588 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
E3S91_RS11245 2300984..2302171 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T148180 WP_000074045.1 NZ_CP047835:2297211-2297477 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T148180 NZ_CP047835:2297211-2297477 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT148180 WP_000587619.1 NZ_CP047835:2296954-2297211 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT148180 NZ_CP047835:2296954-2297211 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References