Detailed information of TA system TA148177

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 195443..195623
• Replicon: chromosome
• Accession: NZ_CP047835
• Organism: Staphylococcus aureus strain UP_883

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3S91_RS01205
• Protein ID: WP_001801861.1
• Coordinates: 195528..195623 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	195443..195500 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S91_RS01175	191151..191285	+	135	Protein_196	hypothetical protein	-
E3S91_RS01180	191450..193006	+	1557	WP_000028583.1	type I restriction-modification system subunit M	-
E3S91_RS01185	192999..194228	+	1230	WP_047230715.1	restriction endonuclease subunit S	-
E3S91_RS01190	194680..195174	+	495	Protein_199	transposase	-
E3S91_RS01195	195165..195326	+	162	Protein_200	transposase	-
E3S91_RS01200	195304..195405	-	102	WP_001792025.1	hypothetical protein	-
-	195443..195500	+	58	-	-	Antitoxin
E3S91_RS01205	195528..195623	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
E3S91_RS01210	195768..196780	+	1013	Protein_203	IS3 family transposase	-
E3S91_RS01215	196979..197551	-	573	WP_000414215.1	hypothetical protein	-
E3S91_RS01220	197652..197993	-	342	WP_000627537.1	DUF3969 family protein	-
E3S91_RS01225	198034..198660	-	627	WP_000669026.1	hypothetical protein	-
E3S91_RS01230	198735..199730	-	996	WP_000070641.1	DUF4352 domain-containing protein	-
E3S91_RS01235	199811..200461	-	651	WP_072470537.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hlgC / lukD	158607..200425	41818

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T148177 WP_001801861.1 NZ_CP047835:c195623-195528 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T148177 NZ_CP063467:3986570-3986884 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT148177 NZ_CP047835:195443-195500 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin