Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2339112..2339296 Replicon chromosome
Accession NZ_CP047833
Organism Staphylococcus aureus strain UP_926

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag E3S92_RS11455 Protein ID WP_000482647.1
Coordinates 2339112..2339219 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2339236..2339296 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S92_RS11430 2334476..2334949 + 474 WP_000456491.1 GyrI-like domain-containing protein -
E3S92_RS11435 2335072..2336283 - 1212 WP_001191975.1 multidrug effflux MFS transporter -
E3S92_RS11440 2336463..2337122 - 660 WP_000831298.1 membrane protein -
E3S92_RS11445 2337182..2338324 - 1143 WP_001176860.1 glycerate kinase -
E3S92_RS11450 2338592..2338978 + 387 WP_000779354.1 flippase GtxA -
E3S92_RS11455 2339112..2339219 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2339236..2339296 - 61 - - Antitoxin
E3S92_RS11460 2339791..2341530 + 1740 WP_001064831.1 ABC transporter ATP-binding protein/permease -
E3S92_RS11465 2341579..2343312 + 1734 WP_000488492.1 ABC transporter ATP-binding protein/permease -
E3S92_RS11470 2343543..2343710 + 168 WP_031785511.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T148169 WP_000482647.1 NZ_CP047833:2339112-2339219 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T148169 NZ_CP063467:1396501-1396608 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 61 bp

>AT148169 NZ_CP047833:c2339296-2339236 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References