Detailed information of TA system TA148161

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2414483..2414667
• Replicon: chromosome
• Accession: NZ_CP047830
• Organism: Staphylococcus aureus strain UP_996

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: E3S94_RS11995
• Protein ID: WP_000482650.1
• Coordinates: 2414560..2414667 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2414483..2414543 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S94_RS11980	2410013..2410180	-	168	WP_001790576.1	hypothetical protein	-
E3S94_RS11985	2410411..2412144	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
E3S94_RS11990	2412169..2413932	-	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
-	2414483..2414543	+	61	-	-	Antitoxin
E3S94_RS11995	2414560..2414667	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3S94_RS12000	2414801..2415187	-	387	WP_000779358.1	flippase GtxA	-
E3S94_RS12005	2415455..2416597	+	1143	WP_001176863.1	glycerate kinase	-
E3S94_RS12010	2416657..2417316	+	660	WP_000831298.1	membrane protein	-
E3S94_RS12015	2417498..2418709	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S94_RS12020	2418832..2419305	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148161 WP_000482650.1 NZ_CP047830:c2414667-2414560 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148161 NZ_CP063462:124033-124320 [Escherichia coli]
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT148161 NZ_CP047830:2414483-2414543 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin