Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2389135..2389652 Replicon chromosome
Accession NZ_CP047830
Organism Staphylococcus aureus strain UP_996

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E3S94_RS11860 Protein ID WP_000113262.1
Coordinates 2389135..2389401 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3S94_RS11865 Protein ID WP_000584499.1
Coordinates 2389401..2389652 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S94_RS11830 2384561..2385097 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E3S94_RS11835 2385330..2386154 - 825 WP_000572040.1 formate/nitrite transporter family protein -
E3S94_RS11840 2386371..2386553 - 183 WP_000230294.1 hypothetical protein -
E3S94_RS11845 2386637..2387104 - 468 WP_000153344.1 SRPBCC domain-containing protein -
E3S94_RS11850 2387290..2388840 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S94_RS11855 2389029..2389100 - 72 Protein_2274 hypothetical protein -
E3S94_RS11860 2389135..2389401 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E3S94_RS11865 2389401..2389652 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S94_RS11870 2389817..2389918 - 102 WP_001791744.1 hypothetical protein -
E3S94_RS11875 2389925..2390524 - 600 WP_000162813.1 DsbA family protein -
E3S94_RS11880 2390543..2390902 - 360 WP_000819847.1 DUF4467 domain-containing protein -
E3S94_RS11885 2391157..2392407 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
E3S94_RS11890 2392504..2393235 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3S94_RS11895 2393232..2393951 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T148160 WP_000113262.1 NZ_CP047830:c2389401-2389135 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148160 NZ_CP063462:120444-120650 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCTTTGCTGAGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGAG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT148160 WP_000584499.1 NZ_CP047830:c2389652-2389401 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT148160 NZ_CP063462:c120457-120396 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References