Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2124509..2124772 Replicon chromosome
Accession NZ_CP047830
Organism Staphylococcus aureus strain UP_996

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag E3S94_RS10480 Protein ID WP_001802298.1
Coordinates 2124668..2124772 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2124509..2124673 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S94_RS10460 2120692..2121357 - 666 WP_001024094.1 SDR family oxidoreductase -
E3S94_RS10465 2121509..2121829 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
E3S94_RS10470 2121831..2122811 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
E3S94_RS10475 2123077..2124168 + 1092 WP_000495671.1 lytic regulatory protein -
- 2124509..2124673 + 165 - - Antitoxin
E3S94_RS10480 2124668..2124772 - 105 WP_001802298.1 hypothetical protein Toxin
E3S94_RS10485 2124933..2125416 - 484 Protein_2008 recombinase family protein -
E3S94_RS10490 2125459..2126595 - 1137 WP_000115564.1 SAP domain-containing protein -
E3S94_RS10495 2126884..2126976 + 93 WP_001790138.1 hypothetical protein -
E3S94_RS10500 2127681..2128538 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
E3S94_RS10505 2128606..2129388 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-48)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T148159 WP_001802298.1 NZ_CP047830:c2124772-2124668 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T148159 NZ_CP063462:104777-104938 [Escherichia coli]
ATGAAACTACCGGGAAACGCCCTTATCTGGTGCGTATTAATCGTGTGCTGCACGTTGTTAATATTCACACTCCTGACCCG
GAATCGTCTGTGCGAAGTCCGGCTGAAGGACGGATACAGGGAGGTTACGGCAAGTTTGGCTTACGAATCCAGCGGTAAGT
AG

Antitoxin


Download         Length: 165 bp

>AT148159 NZ_CP047830:2124509-2124673 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References