Detailed information of TA system TA148154

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1832029..1832211
• Replicon: chromosome
• Accession: NZ_CP047830
• Organism: Staphylococcus aureus strain UP_996

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3S94_RS08835
• Protein ID: WP_001801861.1
• Coordinates: 1832029..1832124 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1832152..1832211 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S94_RS08795	1827689..1828315	+	627	WP_000669046.1	hypothetical protein	-
E3S94_RS08800	1828356..1828700	+	345	WP_000627551.1	DUF3969 family protein	-
E3S94_RS08805	1828798..1829349	+	552	WP_000414205.1	hypothetical protein	-
E3S94_RS08810	1829567..1830208	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
E3S94_RS08815	1830322..1830507	-	186	WP_000809857.1	hypothetical protein	-
E3S94_RS08820	1830509..1830685	-	177	WP_000375476.1	hypothetical protein	-
E3S94_RS08825	1830696..1831079	-	384	WP_000070811.1	hypothetical protein	-
E3S94_RS08830	1831683..1831826	-	144	WP_001549059.1	transposase	-
E3S94_RS08835	1832029..1832124	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1832152..1832211	-	60	-	-	Antitoxin
E3S94_RS08840	1832247..1832348	+	102	WP_001791893.1	hypothetical protein	-
E3S94_RS08845	1832326..1832502	-	177	Protein_1726	transposase	-
E3S94_RS08850	1832696..1833073	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1805985..1865298	59313

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T148154 WP_001801861.1 NZ_CP047830:1832029-1832124 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T148154 NZ_CP063459:4608990-4609208 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT148154 NZ_CP047830:c1832211-1832152 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin