Detailed information of TA system TA148149

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2310524..2310708
• Replicon: chromosome
• Accession: NZ_CP047828
• Organism: Staphylococcus aureus strain UP_1073

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S96_RS11275
• Protein ID: WP_000482647.1
• Coordinates: 2310524..2310631 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2310648..2310708 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S96_RS11250	2305888..2306361	+	474	WP_000456491.1	GyrI-like domain-containing protein	-
E3S96_RS11255	2306484..2307695	-	1212	WP_001191975.1	multidrug effflux MFS transporter	-
E3S96_RS11260	2307875..2308534	-	660	WP_000831298.1	membrane protein	-
E3S96_RS11265	2308594..2309736	-	1143	WP_001176860.1	glycerate kinase	-
E3S96_RS11270	2310004..2310390	+	387	WP_000779354.1	flippase GtxA	-
E3S96_RS11275	2310524..2310631	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2310648..2310708	-	61	-	-	Antitoxin
E3S96_RS11280	2310658..2310825	+	168	WP_000301894.1	hypothetical protein	-
E3S96_RS11285	2311203..2312942	+	1740	WP_001064831.1	ABC transporter ATP-binding protein/permease	-
E3S96_RS11290	2312991..2314724	+	1734	WP_000488492.1	ABC transporter ATP-binding protein/permease	-
E3S96_RS11295	2314955..2315122	+	168	WP_031785511.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T148149 WP_000482647.1 NZ_CP047828:2310524-2310631 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148149 NZ_CP063459:2963954-2964208 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148149 NZ_CP047828:c2310708-2310648 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin