Detailed information of TA system TA148146

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 18831..19138
• Replicon: chromosome
• Accession: NZ_CP047828
• Organism: Staphylococcus aureus strain UP_1073

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3S96_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 18831..19007 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	18997..19138 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S96_RS00085	14066..17851	+	3786	WP_000582165.1	hypothetical protein	-
E3S96_RS00090	17841..17993	+	153	WP_001153681.1	hypothetical protein	-
E3S96_RS00095	18040..18327	+	288	WP_001040261.1	hypothetical protein	-
E3S96_RS00100	18385..18681	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
E3S96_RS00105	18831..19007	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	18997..19138	-	142	-	-	Antitoxin
E3S96_RS00115	19219..19473	+	255	WP_000611512.1	phage holin	-
E3S96_RS00120	19485..20240	+	756	WP_000861038.1	CHAP domain-containing protein	-
E3S96_RS00125	20431..20922	+	492	WP_000919350.1	staphylokinase	-
E3S96_RS00130	21571..21906	+	336	Protein_25	SH3 domain-containing protein	-
E3S96_RS00135	22001..22450	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
E3S96_RS00140	23134..23484	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3S96_RS00145	23537..23797	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn / hlb / map	1..73397	73396

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T148146 WP_011447039.1 NZ_CP047828:18831-19007 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T148146 NZ_CP063459:2232341-2232652 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Nucleotide

• Length: 142 bp

>AT148146 NZ_CP047828:c19138-18997 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin