Detailed information of TA system TA148138

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2591803..2592082
• Replicon: chromosome
• Accession: NZ_CP047826
• Organism: Staphylococcus aureus strain UP_1239

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3T01_RS12695
• Protein ID: WP_001802298.1
• Coordinates: 2591803..2591907 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2591903..2592082 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T01_RS12670	2587187..2587969	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
E3T01_RS12675	2588037..2588894	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
E3T01_RS12680	2589599..2589691	-	93	WP_001790138.1	hypothetical protein	-
E3T01_RS12685	2589980..2591116	+	1137	WP_000115564.1	SAP domain-containing protein	-
E3T01_RS12690	2591159..2591642	+	484	Protein_2452	recombinase family protein	-
E3T01_RS12695	2591803..2591907	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2591903..2592082	-	180	-	-	Antitoxin
E3T01_RS12700	2592350..2593441	-	1092	WP_000495683.1	hypothetical protein	-
E3T01_RS12705	2593707..2594687	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
E3T01_RS12710	2594689..2595009	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3T01_RS12715	2595161..2595826	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148138 WP_001802298.1 NZ_CP047826:2591803-2591907 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148138 NZ_CP063459:c442332-441982 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT148138 NZ_CP047826:c2592082-2591903 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin