Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2331671..2332188 Replicon chromosome
Accession NZ_CP047826
Organism Staphylococcus aureus strain UP_1239

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E3T01_RS11355 Protein ID WP_000113262.1
Coordinates 2331922..2332188 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3T01_RS11350 Protein ID WP_000584499.1
Coordinates 2331671..2331922 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T01_RS11320 2327369..2328088 + 720 WP_000479576.1 amino acid ABC transporter permease -
E3T01_RS11325 2328085..2328816 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3T01_RS11330 2328913..2330163 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
E3T01_RS11335 2330418..2330780 + 363 WP_000819840.1 DUF4467 domain-containing protein -
E3T01_RS11340 2330799..2331398 + 600 WP_000162810.1 DsbA family protein -
E3T01_RS11345 2331405..2331506 + 102 Protein_2191 hypothetical protein -
E3T01_RS11350 2331671..2331922 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T01_RS11355 2331922..2332188 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E3T01_RS11360 2332223..2332294 + 72 Protein_2194 hypothetical protein -
E3T01_RS11365 2332483..2334036 + 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3T01_RS11370 2334222..2334689 + 468 WP_000153344.1 SRPBCC domain-containing protein -
E3T01_RS11375 2334773..2334958 + 186 WP_000230293.1 hypothetical protein -
E3T01_RS11380 2335174..2335998 + 825 WP_000594629.1 formate/nitrite transporter family protein -
E3T01_RS11385 2336232..2336768 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T148136 WP_000113262.1 NZ_CP047826:2331922-2332188 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148136 NZ_CP063456:c3036729-3036448 [Pseudomonas shirazica]
ATGACCTATGAACTCGAATTCCTGCCTTCGGCACTGAAAGAGTGGGGCAAGCTAGGCCACACCGTGCGCGAACAGATCAA
GAAAAAACTCGCCGAGCGCCTGCAGTCACCCAAGGTACAGGCCGACGCGCTGCGTGACCTGCCGAACCACTACAAAATCA
AGCTCAAGGCCTCTGGATATCGCCTCGTCTATCGAGTCGAGGAGGAGCGTATCGTTGTAGTGGTGGTATCGGTTGGCAAG
CGCGAGCGTAGCGAGGTGTATCGATCCGCTCAGAAGCGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT148136 WP_000584499.1 NZ_CP047826:2331671-2331922 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT148136 NZ_CP063456:c3036964-3036719 [Pseudomonas shirazica]
ATGCAAAACATATTCGCTGACGTGGCCGTAAGCGTGTCGGAACTGAAAAAGAACCCATCCGCGGTGATGACCGGCGCTGC
GGGTATGCCCGTCGCCGTGCTCAATCACAACCGCGTGATGGGTTACATGGTGCCGGCCGAACTGTACGAGGCCATGATGG
AGCGCTTGGAAGATCTCGAATTGAGCGAACTGGCCAAGTCGAGGTTGGGTGAAAAAGGCGTACCGGTTTCCCTGGATGAC
CTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References