Detailed information of TA system TA148134

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2306697..2306881
• Replicon: chromosome
• Accession: NZ_CP047826
• Organism: Staphylococcus aureus strain UP_1239

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: E3T01_RS11220
• Protein ID: WP_000482652.1
• Coordinates: 2306697..2306804 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2306821..2306881 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T01_RS11195	2302059..2302532	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
E3T01_RS11200	2302655..2303866	-	1212	WP_001191922.1	multidrug effflux MFS transporter	-
E3T01_RS11205	2304048..2304707	-	660	WP_000831298.1	membrane protein	-
E3T01_RS11210	2304767..2305909	-	1143	WP_001176863.1	glycerate kinase	-
E3T01_RS11215	2306177..2306563	+	387	WP_000779357.1	flippase GtxA	-
E3T01_RS11220	2306697..2306804	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2306821..2306881	-	61	-	-	Antitoxin
E3T01_RS11225	2307507..2309270	+	1764	WP_001064837.1	ABC transporter ATP-binding protein/permease	-
E3T01_RS11230	2309295..2311028	+	1734	WP_049307645.1	ABC transporter ATP-binding protein/permease	-
E3T01_RS11235	2311259..2311426	+	168	WP_001789205.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148134 WP_000482652.1 NZ_CP047826:2306697-2306804 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148134 NZ_CP063456:1490341-1490916 [Pseudomonas shirazica]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAATCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTACCCGATCCGAACGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGTGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148134 NZ_CP047826:c2306881-2306821 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin