Detailed information of TA system TA148133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2274857..2275380
• Replicon: chromosome
• Accession: NZ_CP047826
• Organism: Staphylococcus aureus strain UP_1239

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A0E1VXK4
• Locus tag: E3T01_RS11080
• Protein ID: WP_000074045.1
• Coordinates: 2275114..2275380 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0E1VMY7
• Locus tag: E3T01_RS11075
• Protein ID: WP_000587619.1
• Coordinates: 2274857..2275114 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T01_RS11055	2269935..2271128	+	1194	WP_000675407.1	MFS transporter	-
E3T01_RS11060	2271352..2272101	-	750	WP_000072465.1	hypothetical protein	-
E3T01_RS11065	2272297..2273874	+	1578	WP_064626840.1	FMN-binding glutamate synthase family protein	-
E3T01_RS11070	2274042..2274497	-	456	WP_000732079.1	DUF1307 domain-containing protein	-
E3T01_RS11075	2274857..2275114	+	258	WP_000587619.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E3T01_RS11080	2275114..2275380	+	267	WP_000074045.1	Txe/YoeB family addiction module toxin	Toxin
E3T01_RS11085	2275735..2276811	+	1077	WP_160181650.1	M42 family metallopeptidase	-
E3T01_RS11090	2277059..2277721	+	663	WP_000923525.1	ATP-binding cassette domain-containing protein	-
E3T01_RS11095	2277714..2278490	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
E3T01_RS11100	2278886..2280073	+	1188	WP_160181652.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10632.36 Da
• Isoelectric Point: 10.2519

>T148133 WP_000074045.1 NZ_CP047826:2275114-2275380 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T148133 NZ_CP063456:c1367837-1367262 [Pseudomonas shirazica]
ATGAAGCACTCGCCCTTCACGGCCATTTACGACGCGAACGTTCTTTATCCTGCCCCACTCCGTGATTTCCTGATGAACCT
TGCATTGACAGGTATTTACCGAGCACGTTGGTCAACGAAGATTCATGACGAGTGGAAACGCAATTTATTGCTCAACCGGC
CTGACCTCACCCTCGAGCAAGTAGATCGGACGTCACGGCGAATGGACGCTGCTGTACCTGACGCACTCGTAACTGACTAC
GAGTCGCTGGTAGAAGGGCTGGACTTGCCAGATAAGGATGATCGACATGTCCTCGCTGCTGCAATCAAGTGCAACGCTTC
CGTCATCGTCACCTTCAACCTGAAGGATTTCCCCGAAACGGCTCTCGACGTTTTCGATATCGAGCCCTTACACCCGGATG
ACTTCATCGCCGACCTGTGGGACCTGGACAAGGCAGCAGTACTTGAGGCTGCCCAGCGGCAGCGAATGTCCTTGAAAAAC
CCACCTCACAGCGTGCAGCAGTATCTCGACAGACTGCTTCAGCAAAAGCTTCCCGAGTCGGTGAAGTTGCTTTCAGAATT
CAAATTCCTCCTCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9735.76 Da
• Isoelectric Point: 4.1958

>AT148133 WP_000587619.1 NZ_CP047826:2274857-2275114 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT148133 NZ_CP063456:c1368301-1367834 [Pseudomonas shirazica]
ATGACCACCGCCGACCTCTCTCGCAAGATGCTTCCCGATGAGAAAGAGATTGCCGTGGCAGTCGAATCGAGCCGAACGCT
AGCAGCCTTCCTCTCGACAAAATCAGATACCCAACGGATTGAGCTGCTCAATGAAGAGAATCAGCGCCAGGTTGTTGAAG
TACCTACCTTCGCGCTGCGTCTGTTTGGCGAGATTCTCAGCGAGCTGGCTCTGGGGAACTCGGTCAAAGTCGTTCCAATC
CACGCCGAATTGACTACCCAAGAGGCAGCAGACCTACTCAACGTCTCTCGGCCGTACTTGGTAAAACTGCTAGACGAATC
TGTGATTCCTCACACAAAAACGGGTCGCCATCGTCGGGTCAAATTCTCCGACCTGGTTGCCTACAAGGACAAACGTGACG
AGGTAAGCCGTGCCGCAATGGACGCGCTGGCAGCCGAAGCCCAGGAGTTACGGATGGGGTACGAATGA

Structures

Toxin

• AlphaFold DB: A0A0E1VXK4

Antitoxin

• AlphaFold DB: A0A0E1VMY7