Detailed information of TA system TA148123

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2661942..2662221
• Replicon: chromosome
• Accession: NZ_CP047822
• Organism: Staphylococcus aureus strain UP_1278

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3T02_RS13150
• Protein ID: WP_001802298.1
• Coordinates: 2661942..2662046 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2662042..2662221 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T02_RS13125	2657327..2658109	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
E3T02_RS13130	2658177..2659034	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
E3T02_RS13135	2659729..2659830	-	102	WP_045173434.1	hypothetical protein	-
E3T02_RS13140	2660119..2661255	+	1137	WP_000115564.1	SAP domain-containing protein	-
E3T02_RS13145	2661298..2661781	+	484	Protein_2538	recombinase family protein	-
E3T02_RS13150	2661942..2662046	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2662042..2662221	-	180	-	-	Antitoxin
E3T02_RS13155	2662489..2663580	-	1092	WP_000495671.1	lytic regulatory protein	-
E3T02_RS13160	2663846..2664826	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
E3T02_RS13165	2664828..2665148	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3T02_RS13170	2665300..2665965	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148123 WP_001802298.1 NZ_CP047822:2661942-2662046 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148123 NZ_CP063455:c920344-920054 [Pseudomonas protegens]
ATGCGTACCCCAGTGACCCGCTTCGACGCGGCAGAGTACCTCAAGACCCCGGAAGACATGGTGGCCTACCTCGACGCCTG
CTTCGAGGAAGATGCCGGCGACGGCAAGCTGATCCGCGCCGCCCTCAACGACATCGCCCGCGCCCGGGGCATGACCCAGG
TGGCCCGCGACACCGGCCTGGGTCGCGAGAGCCTGTACAAGGCCCTGGGCAGCCAGGGCAATCCCGAGTTCGCGACTATC
ATCAAGGTCATGAAGGCACTGGGACTCAAGCTCCACGTCAGCCCGGCCTGA

Antitoxin

Nucleotide

• Length: 180 bp

>AT148123 NZ_CP047822:c2662221-2662042 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin