Detailed information of TA system TA148119

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2374945..2375129
• Replicon: chromosome
• Accession: NZ_CP047822
• Organism: Staphylococcus aureus strain UP_1278

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3T02_RS11650
• Protein ID: WP_000482647.1
• Coordinates: 2374945..2375052 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2375069..2375129 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T02_RS11625	2370307..2370780	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
E3T02_RS11630	2370903..2372114	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3T02_RS11635	2372296..2372955	-	660	WP_000831298.1	membrane protein	-
E3T02_RS11640	2373015..2374157	-	1143	WP_064131794.1	glycerate kinase	-
E3T02_RS11645	2374425..2374811	+	387	WP_000779360.1	flippase GtxA	-
E3T02_RS11650	2374945..2375052	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2375069..2375129	-	61	-	-	Antitoxin
E3T02_RS11655	2375700..2377463	+	1764	WP_045172654.1	ABC transporter ATP-binding protein/permease	-
E3T02_RS11660	2377488..2379221	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
E3T02_RS11665	2379452..2379619	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T148119 WP_000482647.1 NZ_CP047822:2374945-2375052 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148119 NZ_CP063450:c5162661-5162413 [Rhodococcus pyridinivorans]
ATGGCTGCCATCACTGCTACCGAAGCGAGAAAAAACTTCTTTCCACTGCTCGAACAGGTCAACAAGGACCACACCCCTGT
GGAAATCGTATCCAAGCGGGGCAATGCCGTCCTGATGTCGAAGGATGACTACGACGCCATGCTCGAGACCTCGTACCTGA
TGCAGTCCCCGGCCAACGCCCGACGACTGCTCGCCAGCATGCAGAGAGCTCGCGGAGGTGAATACACCGAAAGGGAACTC
GTCGAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148119 NZ_CP047822:c2375129-2375069 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin