Detailed information of TA system TA148118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2342070..2342593
• Replicon: chromosome
• Accession: NZ_CP047822
• Organism: Staphylococcus aureus strain UP_1278

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: E3T02_RS11505
• Protein ID: WP_000074043.1
• Coordinates: 2342327..2342593 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: E3T02_RS11500
• Protein ID: WP_000587618.1
• Coordinates: 2342070..2342327 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T02_RS11480	2337150..2338343	+	1194	WP_000675406.1	MFS transporter	-
E3T02_RS11485	2338567..2339316	-	750	WP_000072463.1	hypothetical protein	-
E3T02_RS11490	2339511..2341088	+	1578	WP_000143494.1	FMN-binding glutamate synthase family protein	-
E3T02_RS11495	2341256..2341711	-	456	WP_000732091.1	DUF1307 domain-containing protein	-
E3T02_RS11500	2342070..2342327	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E3T02_RS11505	2342327..2342593	+	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
E3T02_RS11510	2342950..2344026	+	1077	WP_045172647.1	M42 family metallopeptidase	-
E3T02_RS11515	2344274..2344936	+	663	WP_006191024.1	ATP-binding cassette domain-containing protein	-
E3T02_RS11520	2344929..2345705	+	777	WP_006191020.1	iron export ABC transporter permease subunit FetB	-
E3T02_RS11525	2346099..2347286	+	1188	WP_160194439.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T148118 WP_000074043.1 NZ_CP047822:2342327-2342593 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T148118 NZ_CP063450:c5162416-5162162 [Rhodococcus pyridinivorans]
GTGAACATCACCTTCACCGACGAAGCCTGGGACGACTACCAGTTCTGGATCTCGACCGACAGAAAACAGCTCAAGCGTGT
CAACGAGCTGATCAGGGATTGCCAACGAGACCCGTACTCGGGGATCGGCAAACCCGAACGGCTCAGACATGCCCTGTCAG
GACTGTGGTCTCGACGTATCGACAAAGAACACCGCCTGGTCTACGAGGTCATCGACGGTGCCCTGGTCATCATCGCCGCC
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT148118 WP_000587618.1 NZ_CP047822:2342070-2342327 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT148118 NZ_CP063450:c5162661-5162413 [Rhodococcus pyridinivorans]
ATGGCTGCCATCACTGCTACCGAAGCGAGAAAAAACTTCTTTCCACTGCTCGAACAGGTCAACAAGGACCACACCCCTGT
GGAAATCGTATCCAAGCGGGGCAATGCCGTCCTGATGTCGAAGGATGACTACGACGCCATGCTCGAGACCTCGTACCTGA
TGCAGTCCCCGGCCAACGCCCGACGACTGCTCGCCAGCATGCAGAGAGCTCGCGGAGGTGAATACACCGAAAGGGAACTC
GTCGAGTGA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2