Detailed information of TA system TA148113

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18846..19184
• Replicon: chromosome
• Accession: NZ_CP047822
• Organism: Staphylococcus aureus strain UP_1278

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3T02_RS00100
• Protein ID: WP_011447039.1
• Coordinates: 18846..19022 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19010..19184 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T02_RS00080	14081..17866	+	3786	WP_160194357.1	hypothetical protein	-
E3T02_RS00085	17856..18008	+	153	WP_001153681.1	hypothetical protein	-
E3T02_RS00090	18055..18342	+	288	WP_001040261.1	hypothetical protein	-
E3T02_RS00095	18400..18696	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
E3T02_RS00100	18846..19022	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	19010..19184	-	175	-	-	Antitoxin
E3T02_RS00110	19234..19488	+	255	WP_000611512.1	phage holin	-
E3T02_RS00115	19500..20255	+	756	WP_000861038.1	CHAP domain-containing protein	-
E3T02_RS00120	20446..20937	+	492	WP_000920037.1	staphylokinase	-
E3T02_RS00125	21587..21922	+	336	Protein_24	SH3 domain-containing protein	-
E3T02_RS00130	22017..22466	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
E3T02_RS00135	23151..23501	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3T02_RS00140	23554..23814	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn / map	1..27312	27311

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T148113 WP_011447039.1 NZ_CP047822:18846-19022 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T148113 NZ_CP063447:161160-161462 [Novosphingobium sp. ES2-1]
GTGCCTCGCTTTCGCTTAACGCGCGCCGCCGCCGAAGATCTGACAGCCATCTTTCTCCAAGGCATCGAGCAGTTCGGACT
GCCTCAGGCCGATACCTATCACGAAGGGCTGAGCGCGATCTTCGAGTTTCTTGCCGACTATCCCCAAGCTGCGCGATTGC
GAGAGGAAATATCACCTCCTGTCCGCGTGCATCCCTACAAGGCGCATCTGGTGATTTATGATGTCGGAGATGAGGACAAG
GTCATCATTCTGCGTGTCCGGCATGGTCGAGAAGATTGGATATCCTCGAATTACCACGGTTAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT148113 NZ_CP047822:c19184-19010 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin