Detailed information of TA system TA148107

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2607556..2607819
• Replicon: chromosome
• Accession: NZ_CP047820
• Organism: Staphylococcus aureus strain UP_1395

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3T05_RS12850
• Protein ID: WP_001802298.1
• Coordinates: 2607556..2607660 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2607655..2607819 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T05_RS12825	2602940..2603722	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
E3T05_RS12830	2603790..2604647	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
E3T05_RS12835	2605352..2605444	-	93	WP_001790138.1	hypothetical protein	-
E3T05_RS12840	2605733..2606869	+	1137	WP_000115564.1	SAP domain-containing protein	-
E3T05_RS12845	2606912..2607395	+	484	Protein_2481	recombinase family protein	-
E3T05_RS12850	2607556..2607660	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2607655..2607819	-	165	-	-	Antitoxin
E3T05_RS12855	2608160..2609251	-	1092	WP_000495671.1	lytic regulatory protein	-
E3T05_RS12860	2609517..2610497	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
E3T05_RS12865	2610499..2610819	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3T05_RS12870	2610971..2611636	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148107 WP_001802298.1 NZ_CP047820:2607556-2607660 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148107 NZ_CP063441:1600322-1600675 [Enterobacter asburiae]
GTGTGGGCAATTAACACGACGGACAGGTTTGATCGCTGGTTCACTTCGCTTGACGATACCGAACGCGCCAGCGTACTTGC
AGCGCTGCTGGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGGCCCTACGCCGATACGCTTAAAGGCTCTCGTCACAGCA
ATATGAAAGAGCTACGTATTCAGAGTAAGGGCGATCCCTTGCGGGCGTTTTTCGCCTTTGATCCAAACCGAATGGGTATC
GTGCTTTGTGCGGGCAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGATCGGGAATTCAC
TCACTGGCTGAATACATTAAAAGAGAGGGAATAG

Antitoxin

Nucleotide

• Length: 165 bp

>AT148107 NZ_CP047820:c2607819-2607655 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin