Detailed information of TA system TA148104

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2317408..2317592
• Replicon: chromosome
• Accession: NZ_CP047820
• Organism: Staphylococcus aureus strain UP_1395

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: E3T05_RS11335
• Protein ID: WP_000482650.1
• Coordinates: 2317408..2317515 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2317532..2317592 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T05_RS11310	2312770..2313243	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
E3T05_RS11315	2313366..2314577	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3T05_RS11320	2314759..2315418	-	660	WP_000831298.1	membrane protein	-
E3T05_RS11325	2315478..2316620	-	1143	WP_001176863.1	glycerate kinase	-
E3T05_RS11330	2316888..2317274	+	387	WP_000779358.1	flippase GtxA	-
E3T05_RS11335	2317408..2317515	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2317532..2317592	-	61	-	-	Antitoxin
E3T05_RS11340	2318143..2319906	+	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
E3T05_RS11345	2319931..2321664	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
E3T05_RS11350	2321895..2322062	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148104 WP_000482650.1 NZ_CP047820:2317408-2317515 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148104 NZ_CP063441:c257121-256834 [Enterobacter asburiae]
ATGCATAAATTAACATCCTACGATCCAGCAAACGCGCTGGTGGATGATGAGGAAATCGCCGTGTTTATGGCTGATGCCTT
AGAAACGGGCGACTCAGCGTATATTGCTAAAGCGCTGGGCGTCATCGCGCGCGCGAAAGGAATGTCGACCATTTCACAGC
AAACTGGCCTATCACGAGAGCAACTATATCGATCGTTCAGTGATAAAGGAAACCCAACGCTTAAAACCACTCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTAACAATCAAACACGCCGGAGATTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148104 NZ_CP047820:c2317592-2317532 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin