Detailed information of TA system TA148090

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2587155..2587417
• Replicon: chromosome
• Accession: NZ_CP047817
• Organism: Staphylococcus aureus strain UP_1433

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3T06_RS12675
• Protein ID: WP_001802298.1
• Coordinates: 2587155..2587259 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2587254..2587417 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T06_RS12660	2583952..2584734	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
E3T06_RS12665	2584802..2585659	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
E3T06_RS12670	2586317..2586475	-	159	WP_001792784.1	hypothetical protein	-
E3T06_RS12675	2587155..2587259	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2587254..2587417	-	164	-	-	Antitoxin
E3T06_RS12680	2587692..2588783	-	1092	WP_000495669.1	hypothetical protein	-
E3T06_RS12685	2589049..2590026	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
E3T06_RS12690	2590028..2590348	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3T06_RS12695	2590500..2591165	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148090 WP_001802298.1 NZ_CP047817:2587155-2587259 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148090 NZ_CP063427:c1184050-1183832 [Citrobacter sp. BDA59-3]
ATGTCTGATAAGCCATTAACCAAAATTGATTATTTGATGCGATTACGACGTTGTCAGACAATTGACACGCTCGAACGCGT
TATTGAAAAAAATAAATACGAACTGCCTGACCATGAACTGACGGTGTTTTATTCAGCAGCCGATCATCGTCTGGCTGAGC
TAACCATGAATAAACTGTATGACAAAATCCCTCCTTCTGTGTGGAAATTTGTACGCTAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT148090 NZ_CP047817:c2587417-2587254 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin