Detailed information of TA system TA148087

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2302000..2302184
• Replicon: chromosome
• Accession: NZ_CP047817
• Organism: Staphylococcus aureus strain UP_1433

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: E3T06_RS11200
• Protein ID: WP_000482652.1
• Coordinates: 2302000..2302107 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2302124..2302184 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T06_RS11175	2297362..2297835	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
E3T06_RS11180	2297958..2299169	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3T06_RS11185	2299351..2300010	-	660	WP_000831298.1	membrane protein	-
E3T06_RS11190	2300070..2301212	-	1143	WP_001176863.1	glycerate kinase	-
E3T06_RS11195	2301480..2301866	+	387	WP_000779360.1	flippase GtxA	-
E3T06_RS11200	2302000..2302107	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2302124..2302184	-	61	-	-	Antitoxin
E3T06_RS11205	2302810..2304573	+	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
E3T06_RS11210	2304598..2306331	+	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
E3T06_RS11215	2306562..2306729	+	168	Protein_2164	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148087 WP_000482652.1 NZ_CP047817:2302000-2302107 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148087 NZ_CP063425:c4030904-4030488 [Kosakonia pseudosacchari]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCACAATGGATTTCGTTATTACTGCACGGGCTGGTGGCGGC
GTTCATTCTTTTTATGCCCTGGCCGTTGAGCTATACGCCGCTATGGCTTTTGCTGCTGTCGCTGGTGGTTTTTGATTGCG
TGCGCAGCCAGCGGCGGATCAACGCCTGCCACGGAGAGATCAAACTGCTGATGGATTCCCGCCTGCGCTGGCAAGGTGTG
GAGTGGGATATTATCGGTACACCCTGGATGATCCGCGGCGGTATGATGTTGCGATTACGCCGTGCGGAAGACGGGCGGCG
CCAGCATTTATGGCTGGCGGCAGACAGTATGGATTCGCAGGAGTGGCGCGATCTACGCCGGATGATCACCCAAAATCCGG
CGCAGGGGCTACATTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148087 NZ_CP047817:c2302184-2302124 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin