Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2427079..2427602 Replicon chromosome
Accession NZ_CP047815
Organism Staphylococcus aureus strain UP_1484

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag E3T08_RS11920 Protein ID WP_000074045.1
Coordinates 2427079..2427345 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag E3T08_RS11925 Protein ID WP_000587619.1
Coordinates 2427345..2427602 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T08_RS11900 2422385..2423572 - 1188 WP_000026194.1 MFS transporter -
E3T08_RS11905 2423968..2424744 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
E3T08_RS11910 2424737..2425399 - 663 WP_000923529.1 ATP-binding cassette domain-containing protein -
E3T08_RS11915 2425647..2426723 - 1077 WP_001076673.1 M42 family metallopeptidase -
E3T08_RS11920 2427079..2427345 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
E3T08_RS11925 2427345..2427602 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T08_RS11930 2427708..2427902 - 195 WP_001790145.1 hypothetical protein -
E3T08_RS11935 2427961..2428416 + 456 WP_000732082.1 DUF1307 domain-containing protein -
E3T08_RS11940 2428584..2430161 - 1578 WP_000143491.1 FMN-binding glutamate synthase family protein -
E3T08_RS11945 2430356..2431105 + 750 WP_000072464.1 hypothetical protein -
E3T08_RS11950 2431329..2432522 - 1194 WP_000675406.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T148078 WP_000074045.1 NZ_CP047815:c2427345-2427079 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T148078 NZ_CP063424:c1826186-1825719 [Actinobacillus pleuropneumoniae]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGCGTGATGAGAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGCGCATTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGCTCAGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAATCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAATCCGCAAGCAAAAC
AATTTTATTTAAAGTACGGTTTTTCATGTTCACCCATTGATGAGATAGTTTTAATGTTAAAACTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT148078 WP_000587619.1 NZ_CP047815:c2427602-2427345 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT148078 NZ_CP063424:c1826450-1826190 [Actinobacillus pleuropneumoniae]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References