Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2370223..2370740 Replicon chromosome
Accession NZ_CP047815
Organism Staphylococcus aureus strain UP_1484

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E3T08_RS11645 Protein ID WP_000113262.1
Coordinates 2370223..2370489 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3T08_RS11650 Protein ID WP_000584499.1
Coordinates 2370489..2370740 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T08_RS11620 2365646..2366182 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E3T08_RS11625 2366416..2367240 - 825 WP_000572040.1 formate/nitrite transporter family protein -
E3T08_RS11630 2367457..2367639 - 183 WP_000079142.1 hypothetical protein -
E3T08_RS11635 2367726..2368193 - 468 WP_000153344.1 SRPBCC domain-containing protein -
E3T08_RS11640 2368379..2369929 - 1551 WP_042909117.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3T08_RS11645 2370223..2370489 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E3T08_RS11650 2370489..2370740 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T08_RS11655 2370905..2371006 - 102 Protein_2237 hypothetical protein -
E3T08_RS11660 2371013..2371612 - 600 WP_000162810.1 DsbA family protein -
E3T08_RS11665 2371631..2371993 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E3T08_RS11670 2372248..2373498 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
E3T08_RS11675 2373595..2374326 - 732 WP_042909118.1 amino acid ABC transporter ATP-binding protein -
E3T08_RS11680 2374323..2375042 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T148075 WP_000113262.1 NZ_CP047815:c2370489-2370223 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148075 NZ_CP063424:c297754-297494 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGTCTGATTAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAGCCTGAACCGCTAAAATTCAATCTTTCGG
GCTTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACACCGTGGAAGATGAAACAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT148075 WP_000584499.1 NZ_CP047815:c2370740-2370489 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT148075 NZ_CP063424:c298002-297751 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACAATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATAGTTCACTTGAAGAAACCGCCTATT
TAATGCGTTCCCCGGCTAACGCTCAAAGATTACTAGACAGCATGGCAGAATTGAAGCAAGGGAAAGGCATTGAAAGAGAG
CTAATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References