Detailed information of TA system TA148074

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-sprA1AS/-
• Location: 2117464..2117661
• Replicon: chromosome
• Accession: NZ_CP047815
• Organism: Staphylococcus aureus strain UP_1484

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3T08_RS10335
• Protein ID: WP_001802298.1
• Coordinates: 2117557..2117661 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2117464..2117502 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T08_RS10315	2112472..2112792	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3T08_RS10320	2112794..2113774	+	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
E3T08_RS10325	2114040..2115131	+	1092	WP_160188392.1	transcriptional regulator	-
E3T08_RS10330	2115160..2116806	-	1647	WP_000277718.1	IS1182 family transposase	-
-	2117464..2117502	+	39	-	-	Antitoxin
E3T08_RS10335	2117557..2117661	-	105	WP_001802298.1	hypothetical protein	Toxin
E3T08_RS10340	2118341..2118499	+	159	WP_001792784.1	hypothetical protein	-
E3T08_RS10345	2119158..2120015	-	858	WP_000370931.1	Cof-type HAD-IIB family hydrolase	-
E3T08_RS10350	2120083..2120865	-	783	WP_000908174.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2115160..2116806	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148074 WP_001802298.1 NZ_CP047815:c2117661-2117557 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148074 NZ_CP063424:211158-211529 [Actinobacillus pleuropneumoniae]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Nucleotide

• Length: 39 bp

>AT148074 NZ_CP047815:2117464-2117502 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin