Detailed information of TA system TA148063

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2578359..2578621
• Replicon: chromosome
• Accession: NZ_CP047813
• Organism: Staphylococcus aureus strain UP_1500

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3T09_RS12665
• Protein ID: WP_001802298.1
• Coordinates: 2578359..2578463 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2578458..2578621 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T09_RS12650	2575156..2575938	+	783	WP_043044040.1	ABC transporter ATP-binding protein	-
E3T09_RS12655	2576006..2576863	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
E3T09_RS12660	2577521..2577679	-	159	WP_001792784.1	hypothetical protein	-
E3T09_RS12665	2578359..2578463	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2578458..2578621	-	164	-	-	Antitoxin
E3T09_RS12670	2578962..2580053	-	1092	WP_000495682.1	hypothetical protein	-
E3T09_RS12675	2580319..2581299	-	981	WP_043044038.1	CDF family zinc efflux transporter CzrB	-
E3T09_RS12680	2581301..2581621	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3T09_RS12685	2581773..2582438	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148063 WP_001802298.1 NZ_CP047813:2578359-2578463 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148063 NZ_CP063421:c174018-173521 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCCCTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGCGTAGCGTTCCCTGTTGTCATTGTTGATGCTAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin

Nucleotide

• Length: 164 bp

>AT148063 NZ_CP047813:c2578621-2578458 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin