Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2317428..2317945 Replicon chromosome
Accession NZ_CP047813
Organism Staphylococcus aureus strain UP_1500

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E3T09_RS11310 Protein ID WP_000113262.1
Coordinates 2317679..2317945 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3T09_RS11305 Protein ID WP_000584499.1
Coordinates 2317428..2317679 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T09_RS11275 2313126..2313845 + 720 WP_000479576.1 amino acid ABC transporter permease -
E3T09_RS11280 2313842..2314573 + 732 WP_043044960.1 amino acid ABC transporter ATP-binding protein -
E3T09_RS11285 2314670..2315920 - 1251 WP_043044961.1 FemA/FemB family glycyltransferase FmhA -
E3T09_RS11290 2316175..2316537 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3T09_RS11295 2316556..2317155 + 600 WP_000162813.1 DsbA family protein -
E3T09_RS11300 2317162..2317263 + 102 WP_001791744.1 hypothetical protein -
E3T09_RS11305 2317428..2317679 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T09_RS11310 2317679..2317945 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E3T09_RS11315 2317980..2318051 + 72 Protein_2182 hypothetical protein -
E3T09_RS11320 2318240..2319790 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3T09_RS11325 2319976..2320443 + 468 WP_000153344.1 SRPBCC domain-containing protein -
E3T09_RS11330 2320527..2320712 + 186 WP_000230293.1 hypothetical protein -
E3T09_RS11335 2320928..2321752 + 825 WP_000594630.1 formate/nitrite transporter family protein -
E3T09_RS11340 2321986..2322522 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T148062 WP_000113262.1 NZ_CP047813:2317679-2317945 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148062 NZ_CP063421:165249-165515 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT148062 WP_000584499.1 NZ_CP047813:2317428-2317679 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT148062 NZ_CP063421:165502-165747 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References