Detailed information of TA system TA148056

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 172818..172998
• Replicon: chromosome
• Accession: NZ_CP047813
• Organism: Staphylococcus aureus strain UP_1500

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3T09_RS01065
• Protein ID: WP_001801861.1
• Coordinates: 172903..172998 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	172818..172875 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T09_RS01040	170732..171175	+	444	WP_000747799.1	DUF1433 domain-containing protein	-
E3T09_RS01045	171175..171618	+	444	WP_043044079.1	DUF1433 domain-containing protein	-
E3T09_RS01050	171618..172061	+	444	WP_043044078.1	DUF1433 domain-containing protein	-
E3T09_RS01055	172061..172503	+	443	Protein_169	DUF1433 domain-containing protein	-
E3T09_RS01060	172679..172780	-	102	WP_001791232.1	hypothetical protein	-
-	172818..172875	+	58	-	-	Antitoxin
E3T09_RS01065	172903..172998	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
E3T09_RS01070	173143..174227	+	1085	WP_104011150.1	IS3 family transposase	-
E3T09_RS01075	174426..174998	-	573	WP_023914802.1	hypothetical protein	-
E3T09_RS01080	175099..175440	-	342	WP_000627540.1	DUF3969 family protein	-
E3T09_RS01085	175481..176107	-	627	WP_043044073.1	hypothetical protein	-
E3T09_RS01090	176182..177177	-	996	WP_043044072.1	DUF4352 domain-containing protein	-
E3T09_RS01095	177258..177908	-	651	WP_072490651.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD / hysA	117317..177872	60555

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T148056 WP_001801861.1 NZ_CP047813:c172998-172903 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T148056 NZ_CP063404:c95511-95029 [Klebsiella variicola]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGTCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGCACGCAAAACATTGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT148056 NZ_CP047813:172818-172875 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin