Detailed information of TA system TA148052

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19412..19750
• Replicon: chromosome
• Accession: NZ_CP047813
• Organism: Staphylococcus aureus strain UP_1500

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: E3T09_RS00100
• Protein ID: WP_072353918.1
• Coordinates: 19412..19588 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19576..19750 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T09_RS00080	14579..18361	+	3783	WP_000582128.1	hypothetical protein	-
E3T09_RS00085	18354..18506	+	153	WP_001000058.1	hypothetical protein	-
E3T09_RS00090	18552..18839	+	288	WP_001262620.1	hypothetical protein	-
E3T09_RS00095	18895..19269	+	375	WP_000340977.1	hypothetical protein	-
E3T09_RS00100	19412..19588	+	177	WP_072353918.1	putative holin-like toxin	Toxin
-	19576..19750	-	175	-	-	Antitoxin
E3T09_RS00110	19800..20054	+	255	WP_000611512.1	phage holin	-
E3T09_RS00115	20066..20821	+	756	WP_000861038.1	CHAP domain-containing protein	-
E3T09_RS00120	21012..21503	+	492	WP_000920038.1	staphylokinase	-
E3T09_RS00125	22154..22489	+	336	Protein_24	SH3 domain-containing protein	-
E3T09_RS00130	23000..23350	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3T09_RS00135	23403..23663	-	261	WP_001791826.1	hypothetical protein	-
E3T09_RS00140	23974..24153	-	180	WP_000669791.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn / map	1..74015	74014

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T148052 WP_072353918.1 NZ_CP047813:19412-19588 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T148052 NZ_CP063403:1908706-1908808 [Klebsiella variicola]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 175 bp

>AT148052 NZ_CP047813:c19750-19576 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin