Detailed information of TA system TA148048

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2319831..2320015
• Replicon: chromosome
• Accession: NZ_CP047811
• Organism: Staphylococcus aureus strain UP_1522

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3T10_RS11395
• Protein ID: WP_000482647.1
• Coordinates: 2319831..2319938 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2319955..2320015 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T10_RS11370	2315195..2315668	+	474	WP_000456491.1	GyrI-like domain-containing protein	-
E3T10_RS11375	2315791..2317002	-	1212	WP_001191975.1	multidrug effflux MFS transporter	-
E3T10_RS11380	2317182..2317841	-	660	WP_000831298.1	membrane protein	-
E3T10_RS11385	2317901..2319043	-	1143	WP_001176860.1	glycerate kinase	-
E3T10_RS11390	2319311..2319697	+	387	WP_000779354.1	flippase GtxA	-
E3T10_RS11395	2319831..2319938	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2319955..2320015	-	61	-	-	Antitoxin
E3T10_RS11400	2319965..2320132	+	168	WP_000301894.1	hypothetical protein	-
E3T10_RS11405	2320510..2322249	+	1740	WP_001064831.1	ABC transporter ATP-binding protein/permease	-
E3T10_RS11410	2322298..2324031	+	1734	WP_000488492.1	ABC transporter ATP-binding protein/permease	-
E3T10_RS11415	2324262..2324429	+	168	WP_031785511.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T148048 WP_000482647.1 NZ_CP047811:2319831-2319938 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148048 NZ_CP063403:278688-278963 [Klebsiella variicola]
ATGGAGCAGCAGGTTTTATCTTTACGTAATAAACAGCGCCACACGCTGGAGCAACTGTTTAAAACCCCTGTCCCACAGGG
CATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGCGGGGAGATTAAAGAACGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCATCCTTCGCCGGATACCGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGGGTAAGACCATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148048 NZ_CP047811:c2320015-2319955 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin