148039

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1650563..1651086 Replicon chromosome
Accession NZ_CP047809
Organism Staphylococcus aureus strain UP_1591

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag E3T14_RS08325 Protein ID WP_000074048.1
Coordinates 1650563..1650829 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag E3T14_RS08330 Protein ID WP_000587616.1
Coordinates 1650829..1651086 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T14_RS08305 1645871..1647058 - 1188 WP_000026194.1 MFS transporter -
E3T14_RS08310 1647454..1648230 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
E3T14_RS08315 1648223..1648885 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
E3T14_RS08320 1649132..1650208 - 1077 WP_001076671.1 M42 family metallopeptidase -
E3T14_RS08325 1650563..1650829 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
E3T14_RS08330 1650829..1651086 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T14_RS08335 1651192..1651386 - 195 WP_001790145.1 hypothetical protein -
E3T14_RS08340 1651445..1651900 + 456 WP_161575715.1 YehR family lipoprotein -
E3T14_RS08345 1652068..1653645 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
E3T14_RS08350 1653840..1654589 + 750 WP_000072443.1 hypothetical protein -
E3T14_RS08355 1654813..1656006 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T148039 WP_000074048.1 NZ_CP047809:c1650829-1650563 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T148039 NZ_CP063397:3414686-3414955 [Rhizobium sp. SL42]
ATGATACGGCTGGCCTTTACCGGTGACGGCTGGCAGGACTATCTCTATTGGCAACAGAAGGACCGGAAAACACTGGAGCG
GATCAATGATCTCATTCGCGACACCCTTCGCCAGTCTTTTATCGGCATAGGAAAGCCCGAGCCATTGCAAGGTACATTGA
AGGGTTTCTGGTCACGTCGCATCACGCGGGAACATCGCCTAGTCTATCAGGTCGTCGGGAACGGCGACCACCAAAAGGTC
ATCATCGCGCAATGTCGCTATCACTATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT148039 WP_000587616.1 NZ_CP047809:c1651086-1650829 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT148039 NZ_CP063397:3414423-3414689 [Rhizobium sp. SL42]
ATGGATACGATCTTCTTTTCAAAGGCCCGTGCGGAACTTGCGGGTCTGCTCGACAAGGTGAACGACGATGCAGCGGCGGT
CGAAATCATACGCCGCGACAAGCCATCAGCCGTACTGATGGGCAAAGACGAGTATGACAGCCTGATGGAGACGATCCATC
TCCTGTCCTCACCTGCAAATGCGGAACGGCTTCTGCGCGCCAGCGACGAAATCCGCGAGGGTCGCTATGAAACGATCGAA
GTAAAGACGCTTCTGGGAGCCAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References