Detailed information of TA system TA148037

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1619063..1619247
• Replicon: chromosome
• Accession: NZ_CP047809
• Organism: Staphylococcus aureus strain UP_1591

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: E3T14_RS08185
• Protein ID: WP_000482650.1
• Coordinates: 1619140..1619247 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1619063..1619123 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T14_RS08170	1614593..1614760	-	168	WP_072498102.1	hypothetical protein	-
E3T14_RS08175	1614991..1616724	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
E3T14_RS08180	1616749..1618512	-	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
-	1619063..1619123	+	61	-	-	Antitoxin
E3T14_RS08185	1619140..1619247	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3T14_RS08190	1619381..1619767	-	387	WP_000779358.1	flippase GtxA	-
E3T14_RS08195	1620035..1621177	+	1143	WP_001176863.1	glycerate kinase	-
E3T14_RS08200	1621237..1621896	+	660	WP_000831298.1	membrane protein	-
E3T14_RS08205	1622078..1623289	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3T14_RS08210	1623412..1623885	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T148037 WP_000482650.1 NZ_CP047809:c1619247-1619140 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148037 NZ_CP063397:c2357017-2356763 [Rhizobium sp. SL42]
GTGAAGATCATCTTTCATGCGCGTGCCTGGGAGGATTACCTATATTGGCAGTCCACCGATCAGAAAATGCTGGCGCGCGT
CAATCACCTGATCAGGGAAACCAGCCGGTCACCGTTTCAGGGTATCGGCAAACCGGAGCCGCTGCGGGGTGATCTGCGTG
GCTGGTGGTCGCGGCGGATCGACCAGGAGCATCGGCTCGTCTATCGCCCGACGGAAGATGGCGTACTGATCGCGCAATGC
CGCCATCACTACTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT148037 NZ_CP047809:1619063-1619123 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin