148036

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1593834..1594351 Replicon chromosome
Accession NZ_CP047809
Organism Staphylococcus aureus strain UP_1591

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E3T14_RS08050 Protein ID WP_000113262.1
Coordinates 1593834..1594100 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3T14_RS08055 Protein ID WP_000584499.1
Coordinates 1594100..1594351 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T14_RS08020 1589263..1589799 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E3T14_RS08025 1590032..1590856 - 825 WP_000572040.1 formate/nitrite transporter family protein -
E3T14_RS08030 1591073..1591255 - 183 WP_000230294.1 hypothetical protein -
E3T14_RS08035 1591339..1591806 - 468 WP_000153344.1 SRPBCC domain-containing protein -
E3T14_RS08040 1591992..1593539 - 1548 WP_001551849.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3T14_RS08045 1593728..1593799 - 72 Protein_1545 hypothetical protein -
E3T14_RS08050 1593834..1594100 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E3T14_RS08055 1594100..1594351 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T14_RS08060 1594516..1594617 - 102 WP_001791744.1 hypothetical protein -
E3T14_RS08065 1594624..1595223 - 600 WP_161575713.1 DsbA family protein -
E3T14_RS08070 1595242..1595604 - 363 WP_161575714.1 DUF4467 domain-containing protein -
E3T14_RS08075 1595859..1597109 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
E3T14_RS08080 1597206..1597937 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3T14_RS08085 1597934..1598653 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T148036 WP_000113262.1 NZ_CP047809:c1594100-1593834 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T148036 NZ_CP063397:2308863-2309192 [Rhizobium sp. SL42]
ATGCGGTTTCTCGATGATGCGCAACTGCCTCCCGCGCTCGCGCGCTGGCTCGTTGCATGTGGCCATGAGGCGCAACATCT
TGTCGACCTTGGTATGCAAGGTGCATCGGACAAGATGATATGGGATGTGGCTCTACAGACCAACGCGATCATCATTTCCA
AAGACGAGGACTTTGCGCTTCGCAAGACATTTGACCGATCCGGTCCACCTATTGTCTGGGTGCGGCTACCCAATTCAAGG
CGTCGCGAATTGCTGCAATGGTTTGAGATCATGCTGCCGCAGATGATCAGCGCCCTTGAGCGGGGAGATCATCTTTTCGA
GCTCGCGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT148036 WP_000584499.1 NZ_CP047809:c1594351-1594100 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT148036 NZ_CP063397:2308639-2308863 [Rhizobium sp. SL42]
ATGTCAGAACTTCACAGGATCAGCGTCGACCCGGAAATTTGCTCAGGCCGCCCGACGATTCGTGGGCTGCGGGTTCGCGT
GAAGGATATCCTCGAGCTTCTGGCCGCAGGGGCGAGTCATGAGGAAATCCTCGAAGATTATCCATACCTGGAGCCGTTGG
ACATTGTAGCCGTGCTGGAGTTTGCCGCGCGCCAGGCTGATCACACAATACTTCGTGTCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References