Detailed information of TA system TA148028

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1005170..1005352
• Replicon: chromosome
• Accession: NZ_CP047809
• Organism: Staphylococcus aureus strain UP_1591

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3T14_RS04840
• Protein ID: WP_001801861.1
• Coordinates: 1005170..1005265 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1005293..1005352 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T14_RS04800	1000830..1001456	+	627	WP_000669046.1	hypothetical protein	-
E3T14_RS04805	1001497..1001841	+	345	WP_000627551.1	DUF3969 family protein	-
E3T14_RS04810	1001939..1002490	+	552	WP_161575690.1	hypothetical protein	-
E3T14_RS04815	1002708..1003349	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
E3T14_RS04820	1003463..1003648	-	186	WP_000809857.1	hypothetical protein	-
E3T14_RS04825	1003650..1003826	-	177	WP_000375476.1	hypothetical protein	-
E3T14_RS04830	1003837..1004220	-	384	WP_000070812.1	hypothetical protein	-
E3T14_RS04835	1004824..1004967	-	144	WP_001549059.1	transposase	-
E3T14_RS04840	1005170..1005265	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1005293..1005352	-	60	-	-	Antitoxin
E3T14_RS04845	1005388..1005489	+	102	WP_001791893.1	hypothetical protein	-
E3T14_RS04850	1005467..1005643	-	177	Protein_961	transposase	-
E3T14_RS04855	1005837..1006214	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T148028 WP_001801861.1 NZ_CP047809:1005170-1005265 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T148028 NZ_CP063396:1897312-1897899 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGTGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Nucleotide

• Length: 60 bp

>AT148028 NZ_CP047809:c1005352-1005293 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin