Detailed information of TA system TA148025

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20010..20348
• Replicon: chromosome
• Accession: NZ_CP047809
• Organism: Staphylococcus aureus strain UP_1591

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3T14_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 20010..20186 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20174..20348 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T14_RS00085	17840..17992	+	153	WP_001000058.1	hypothetical protein	-
E3T14_RS00090	18038..18325	+	288	WP_001262621.1	hypothetical protein	-
E3T14_RS00095	18381..18755	+	375	WP_000340977.1	hypothetical protein	-
E3T14_RS00100	19128..19901	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
E3T14_RS00105	20010..20186	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	20174..20348	-	175	-	-	Antitoxin
E3T14_RS00115	20398..20652	+	255	WP_000611512.1	phage holin	-
E3T14_RS00120	20664..21419	+	756	WP_000861038.1	CHAP domain-containing protein	-
E3T14_RS00125	21610..22101	+	492	WP_000920038.1	staphylokinase	-
E3T14_RS00130	22752..23087	+	336	Protein_26	SH3 domain-containing protein	-
E3T14_RS00135	23332..23484	+	153	WP_001788502.1	hypothetical protein	-
E3T14_RS00140	23555..23665	+	111	WP_000139423.1	hypothetical protein	-
E3T14_RS00145	23667..23852	+	186	WP_001286805.1	hypothetical protein	-
E3T14_RS00150	24488..25045	+	558	WP_000528632.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak	1..25045	25044

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T148025 WP_011447039.1 NZ_CP047809:20010-20186 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T148025 NZ_CP063395:c5337331-5336921 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACTATCAAGAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGACACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTATAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT148025 NZ_CP047809:c20348-20174 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin