Detailed information of TA system TA148019

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2531468..2531730
• Replicon: chromosome
• Accession: NZ_CP047807
• Organism: Staphylococcus aureus strain UP_1612

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3T15_RS12480
• Protein ID: WP_001802298.1
• Coordinates: 2531468..2531572 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2531567..2531730 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T15_RS12465	2528265..2529047	+	783	WP_000908180.1	ABC transporter ATP-binding protein	-
E3T15_RS12470	2529115..2529972	+	858	WP_000370930.1	Cof-type HAD-IIB family hydrolase	-
E3T15_RS12475	2530630..2530788	-	159	WP_001792784.1	hypothetical protein	-
E3T15_RS12480	2531468..2531572	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2531567..2531730	-	164	-	-	Antitoxin
E3T15_RS12485	2532014..2533105	-	1092	WP_000495681.1	hypothetical protein	-
E3T15_RS12490	2533371..2534351	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
E3T15_RS12495	2534353..2534673	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3T15_RS12500	2534825..2535490	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T148019 WP_001802298.1 NZ_CP047807:2531468-2531572 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T148019 NZ_CP063394:c5337808-5337398 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACTATCAAGAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGACACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTATAG

Antitoxin

Nucleotide

• Length: 164 bp

>AT148019 NZ_CP047807:c2531730-2531567 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin