Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2857015..2857438 Replicon chromosome
Accession NZ_CP047805
Organism Staphylococcus aureus strain UP_1654

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag E3T17_RS14130 Protein ID WP_001065091.1
Coordinates 2857015..2857266 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag E3T17_RS14135 Protein ID WP_000028422.1
Coordinates 2857256..2857438 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T17_RS14090 2852670..2853590 + 921 WP_000138472.1 recombinase RecT -
E3T17_RS14095 2853671..2854288 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
E3T17_RS14100 2854289..2854759 + 471 WP_000934764.1 single-stranded DNA-binding protein -
E3T17_RS14105 2854789..2855673 + 885 WP_000148316.1 DnaD domain protein -
E3T17_RS14110 2855680..2855898 + 219 WP_000338531.1 hypothetical protein -
E3T17_RS14115 2855907..2856216 + 310 Protein_2736 RusA family crossover junction endodeoxyribonuclease -
E3T17_RS14120 2856229..2856597 + 369 WP_000101274.1 hypothetical protein -
E3T17_RS14125 2856601..2856843 + 243 WP_000131366.1 hypothetical protein -
E3T17_RS14440 2856855..2857022 + 168 WP_001624242.1 hypothetical protein -
E3T17_RS14130 2857015..2857266 + 252 WP_001065091.1 DUF1024 family protein Toxin
E3T17_RS14135 2857256..2857438 + 183 WP_000028422.1 hypothetical protein Antitoxin
E3T17_RS14140 2857431..2857973 + 543 WP_000185659.1 dUTP pyrophosphatase -
E3T17_RS14145 2858010..2858216 + 207 WP_000195803.1 DUF1381 domain-containing protein -
E3T17_RS14150 2858213..2858599 + 387 WP_000592207.1 hypothetical protein -
E3T17_RS14155 2858596..2858745 + 150 WP_000595265.1 transcriptional activator RinB -
E3T17_RS14160 2858745..2858945 + 201 WP_000265043.1 DUF1514 family protein -
E3T17_RS14165 2858973..2859389 + 417 WP_000590122.1 hypothetical protein -
E3T17_RS14170 2859621..2859920 + 300 WP_000988336.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T148007 WP_001065091.1 NZ_CP047805:2857015-2857266 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T148007 NZ_CP063392:c5337336-5336926 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACTATCAAGAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGACACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTATAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT148007 WP_000028422.1 NZ_CP047805:2857256-2857438 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT148007 NZ_CP063392:c5337566-5337336 [Pseudomonas aeruginosa]
GTGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCCGTCGCGCTTCCTGATGACGT
TAAGCGTGTGGATGTGGTCGCTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGCGAGTCTTGGGATAGTTGGTTCGATG
GCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References