Detailed information of TA system TA147998

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2398811..2398995
• Replicon: chromosome
• Accession: NZ_CP047805
• Organism: Staphylococcus aureus strain UP_1654

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3T17_RS11685
• Protein ID: WP_000482647.1
• Coordinates: 2398811..2398918 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2398935..2398995 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T17_RS11660	2394173..2394646	+	474	WP_000456496.1	GyrI-like domain-containing protein	-
E3T17_RS11665	2394769..2395980	-	1212	WP_001191919.1	multidrug effflux MFS transporter	-
E3T17_RS11670	2396162..2396821	-	660	WP_000831298.1	membrane protein	-
E3T17_RS11675	2396881..2398023	-	1143	WP_001176855.1	glycerate kinase	-
E3T17_RS11680	2398291..2398677	+	387	WP_000779351.1	flippase GtxA	-
E3T17_RS11685	2398811..2398918	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2398935..2398995	-	61	-	-	Antitoxin
E3T17_RS11690	2399566..2401329	+	1764	Protein_2266	ABC transporter ATP-binding protein	-
E3T17_RS11695	2401354..2403087	+	1734	WP_000486505.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2403320..2404267	947

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147998 WP_000482647.1 NZ_CP047805:2398811-2398918 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147998 NZ_CP063391:1897312-1897899 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGTGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147998 NZ_CP047805:c2398995-2398935 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin