Detailed information of TA system TA147993

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1093265..1093462
• Replicon: chromosome
• Accession: NZ_CP047805
• Organism: Staphylococcus aureus strain UP_1654

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: E3T17_RS05500
• Protein ID: WP_000623369.1
• Coordinates: 1093355..1093462 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1093265..1093302 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T17_RS05465	1088458..1088745	-	288	WP_000410718.1	hypothetical protein	-
E3T17_RS05470	1089086..1089376	+	291	WP_001791476.1	hypothetical protein	-
E3T17_RS05475	1089464..1090105	-	642	WP_000571191.1	ABC transporter ATP-binding protein	-
E3T17_RS05480	1090102..1090422	-	321	WP_000873929.1	YxeA family protein	-
E3T17_RS05485	1090425..1092389	-	1965	WP_000870819.1	bacteriocin-associated integral membrane family protein	-
E3T17_RS05490	1092433..1092705	-	273	WP_001794574.1	lactococcin 972 family bacteriocin	-
E3T17_RS05495	1092715..1092816	-	102	WP_001790623.1	hypothetical protein	-
-	1093265..1093302	+	38	-	-	Antitoxin
E3T17_RS05500	1093355..1093462	-	108	WP_000623369.1	putative holin-like toxin	Toxin
E3T17_RS05505	1093733..1094335	-	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
E3T17_RS05510	1094350..1094526	-	177	WP_000214898.1	YkvS family protein	-
E3T17_RS05515	1094725..1095711	+	987	Protein_1061	lipoate--protein ligase	-
E3T17_RS05520	1095792..1096010	-	219	WP_000876825.1	IDEAL domain-containing protein	-
E3T17_RS05525	1096220..1096789	+	570	WP_000287265.1	competence protein ComK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T147993 WP_000623369.1 NZ_CP047805:c1093462-1093355 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T147993 NZ_CP063390:1890634-1891221 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGACGTTGCCGCTCGCTGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGTGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Nucleotide

• Length: 38 bp

>AT147993 NZ_CP047805:1093265-1093302 [Staphylococcus aureus]
AACATGTCGCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin