Detailed information of TA system TA147962

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2366204..2366388
• Replicon: chromosome
• Accession: NZ_CP047803
• Organism: Staphylococcus aureus strain UP_1097

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S62_RS11610
• Protein ID: WP_000482647.1
• Coordinates: 2366204..2366311 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2366328..2366388 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S62_RS11585	2361568..2362041	+	474	WP_000456491.1	GyrI-like domain-containing protein	-
E3S62_RS11590	2362164..2363375	-	1212	WP_001191975.1	multidrug effflux MFS transporter	-
E3S62_RS11595	2363555..2364214	-	660	WP_000831298.1	membrane protein	-
E3S62_RS11600	2364274..2365416	-	1143	WP_001176860.1	glycerate kinase	-
E3S62_RS11605	2365684..2366070	+	387	WP_000779354.1	flippase GtxA	-
E3S62_RS11610	2366204..2366311	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2366328..2366388	-	61	-	-	Antitoxin
E3S62_RS11615	2366338..2366505	+	168	WP_000301894.1	hypothetical protein	-
E3S62_RS11620	2366883..2368622	+	1740	WP_001064831.1	ABC transporter ATP-binding protein/permease	-
E3S62_RS11625	2368671..2370404	+	1734	WP_000488492.1	ABC transporter ATP-binding protein/permease	-
E3S62_RS11630	2370635..2370802	+	168	WP_031785511.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147962 WP_000482647.1 NZ_CP047803:2366204-2366311 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147962 NZ_CP063385:1621453-1622322 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACACCCCCGTCCCGAACCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGCCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCTTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGTCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147962 NZ_CP047803:c2366388-2366328 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin