Detailed information of TA system TA147951

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2171266..2171450
• Replicon: chromosome
• Accession: NZ_CP047802
• Organism: Staphylococcus aureus strain UP_1442

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: E3S67_RS11105
• Protein ID: WP_000482652.1
• Coordinates: 2171343..2171450 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2171266..2171326 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S67_RS11090	2166721..2166888	-	168	Protein_2131	hypothetical protein	-
E3S67_RS11095	2167119..2168852	-	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
E3S67_RS11100	2168877..2170640	-	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
-	2171266..2171326	+	61	-	-	Antitoxin
E3S67_RS11105	2171343..2171450	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3S67_RS11110	2171584..2171970	-	387	WP_000779360.1	flippase GtxA	-
E3S67_RS11115	2172238..2173380	+	1143	WP_001176863.1	glycerate kinase	-
E3S67_RS11120	2173440..2174099	+	660	WP_000831298.1	membrane protein	-
E3S67_RS11125	2174281..2175492	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3S67_RS11130	2175615..2176088	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T147951 WP_000482652.1 NZ_CP047802:c2171450-2171343 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147951 NZ_CP063380:c984947-984639 [Pectobacterium versatile]
ATGCAATATAAAGTTTACCGTAATAACGGTAACAGCAACTCATACCCTTACCTGCTCAACATCCAAAGTGACATCATCGG
GGAATTACATACCCGCTTGGTGATACCGTTGTTTCCACTACACAAAATTGCCAGACCACCAGCTCGAAGGCTAACGCCGA
TAGTCACTGTCGAAGGCAACGATTACCTGATAATGACCCATGAAATGGCGAGCGTACGCCGCTCACAACTTGGCCATGAA
GTTATGGATGCGCAGGTGTACCGAAAAACAATCAAGGACGCCGTTGATTTCCTGCTTGATGGGTTCTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147951 NZ_CP047802:2171266-2171326 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin