Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2145727..2146244 Replicon chromosome
Accession NZ_CP047802
Organism Staphylococcus aureus strain UP_1442

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag E3S67_RS10970 Protein ID WP_000113265.1
Coordinates 2145727..2145993 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3S67_RS10975 Protein ID WP_000584499.1
Coordinates 2145993..2146244 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S67_RS10940 2141155..2141691 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E3S67_RS10945 2141925..2142749 - 825 WP_000572038.1 formate/nitrite transporter family protein -
E3S67_RS10950 2142966..2143148 - 183 WP_000230292.1 hypothetical protein -
E3S67_RS10955 2143232..2143699 - 468 WP_000153347.1 SRPBCC domain-containing protein -
E3S67_RS10960 2143885..2145432 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3S67_RS10965 2145621..2145692 - 72 Protein_2106 hypothetical protein -
E3S67_RS10970 2145727..2145993 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
E3S67_RS10975 2145993..2146244 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S67_RS10980 2146409..2146510 - 102 Protein_2109 hypothetical protein -
E3S67_RS10985 2146517..2147116 - 600 WP_000162810.1 DsbA family protein -
E3S67_RS10990 2147135..2147497 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E3S67_RS10995 2147751..2149001 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
E3S67_RS11000 2149098..2149829 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E3S67_RS11005 2149826..2150545 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T147950 WP_000113265.1 NZ_CP047802:c2145993-2145727 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T147950 NZ_CP063380:436400-437287 [Pectobacterium versatile]
ATGCTGAAGCAACAAATTCGCCAAATCGTCCAGTCAACCCCTGACTATGCCGCAGTGACACCCGTCATAGAAAAAGAGAT
CTTGCATCATGACATTATCGATGTGCTGATCAAACAGGGCGTCATGCAGCGGTTAACGTTTATTGGCGGCACCTCATTAC
GAATGTGTTACAACAGTAGCAGGCTATCAGAAGATCTTGATTTCAATGGTGGTCATGATTTCCAGCCCTCAGCGTTTGAG
GGGCTGGAGTCCGAAATCCAAACCTATATTCAGAACAAGTATGAAACCGAAGTTTGGGTAAACAAACCTTCTGGCGAGCA
GCAAGGGGATACCGTTTCTTGGAAAATTAGTATCGTAAAAGAAGCTAATCGTCCTGATTTGCCACGGCAAAAAATGCATA
TTGACGTCTGTGCTATTCCGTCATTTGATATTGAAAAACGCCCACTAATCAATCATTACAACATCGTTGTACCGACTGAA
GGGATCTTGGTTCCGGTACAGTCGTTACAAGAAACATTGGCCGATAAGTTGATCGCGTTAGCGTATCGGGCAAGACGTAT
TAAACCTCGTGATATCTGGGATATTGTTTGGATTAAGCAGCGTGGTATTGATTTATCCAAAACACTGGTTGAAAAGAAGC
TCACCGCCAGACAGAAGCAAACAGAAGACTTTCGACAGGCACTGTCTATTCAGTTAGCCAATCTAATGTCGGAAGATGAA
GTCCGTGACGACTTCAATATGGAAATGAGCCGCTTTATTCCTAAGCAAATTAAAGAGAGAACCCTCGATAATCCTGAATA
TTGGGCTTATGTTCAGGGGGAGGTACATGCCATCGCGTCTGAGTTACTGAATGACGGAACACCAAAAAATCCATTTGATA
TGGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT147950 WP_000584499.1 NZ_CP047802:c2146244-2145993 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT147950 NZ_CP063380:435847-436371 [Pectobacterium versatile]
ATGGCTAAATCTGATGAGCTATTAAGCGCGTTGGCTAAATCAGTGAACGCTGGCGGTGGCATTCACAGTGTAGCAGAGCT
GGCTTTTATGCAGGGTGTGCCTTGTGACTCAGCCTTTAGAAAGTTCCTGGCAGATTGCGTAAAGAAGGGGTTGCTAAGAC
GAGTAGTGAAAGGCTTCTATGAAAGTGTTATTACACCACCTGAGCCTGAGACTGCCATTTATAAAATCATCAAAAAGTTG
CGCAGTGGCGTATTGAACTACATCAGTTTAGAAAGTCAGCTCAGTCATACTGGTGATATTTCACAAGTTGTGATGGGTAG
AGTCACAGTGGTGACTAAAGGTCGAAGTGGTTGTTTTGATACGCCTTATGGCGTGATCGAGTTTACCCATACTAAAAAGC
CAGTCGAGCAAATTGCACCTAATTTGTACTATGACCCCGACATCAAAATGTATCGCGCATACAAGGAACAAGCGATTGCA
GATCTAAAGCACTGCCAGCGCAATCTACATATGTTGGAGAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References